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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanin-concentrating hormone receptor 2
Species	Homo sapiens (Human)
Gene	MCHR2
Synonym	G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor MCH2 G protein-coupled receptor 145 MCH-2R MCH receptor 2 GPRv17 GPR145 MCH-R2 [ Show all ]
Disease	N/A
Length	340
Amino acid sequence	MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProt	Q969V1
Protein Data Bank	N/A
GPCR-HGmod model	Q969V1
3D structure model	This predicted structure model is from GPCR-EXP Q969V1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5038
IUPHAR	281
DrugBank	N/A

Ligand

Name	CHEMBL1934108
Molecular formula	C28H26N2O
IUPAC name	1-[3-(spiro[indene-1,4'-piperidine]-1'-ylmethyl)carbazol-9-yl]ethanone
Molecular weight	406.529
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	5.8
Synonyms	BDBM50360690
Inchi Key	IGTBOBONVJXWNU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H26N2O/c1-20(31)30-26-9-5-3-7-23(26)24-18-21(10-11-27(24)30)19-29-16-14-28(15-17-29)13-12-22-6-2-4-8-25(22)28/h2-13,18H,14-17,19H2,1H3
PubChem CID	57403722
ChEMBL	CHEMBL1934108
IUPHAR	N/A
BindingDB	50360690
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	70.0 nM	PMID22123324	BindingDB,ChEMBL

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