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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesRattus norvegicus (Rat)
GeneGhsr
SynonymGH-releasing peptide receptor
Ghrelin receptor
ghrelin receptor 1a
GHRP
GHS-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length364
Amino acid sequenceMWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProtO08725
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3278
IUPHAR246
DrugBankN/A

Ligand

NameCHEMBL122420
Molecular formulaC32H40N4O3
IUPAC name(E)-5-amino-N,5-dimethyl-N-[(2R)-1-[methyl-[(2R)-1-(methylamino)-1-oxo-3-phenylpropan-2-yl]amino]-3-naphthalen-1-yl-1-oxopropan-2-yl]hex-2-enamide
Molecular weight528.697
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP4.2
SynonymsBDBM50066824
N-(5-Amino-5-methyl-2-hexenoyl)-N-methyl-3-(1-naphthyl)-D-Ala-N-methyl-D-Phe-NHMe
SCHEMBL6318213
(E)-5-Amino-5-methyl-hex-2-enoic acid methyl-{(R)-1-[methyl-((R)-1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-1-yl-ethyl}-amide
SCHEMBL6318847
Inchi KeyIFYWPHLAIJGALZ-YJBBJLKTSA-N
Inchi IDInChI=1S/C32H40N4O3/c1-32(2,33)20-12-19-29(37)35(4)28(22-25-17-11-16-24-15-9-10-18-26(24)25)31(39)36(5)27(30(38)34-3)21-23-13-7-6-8-14-23/h6-19,27-28H,20-22,33H2,1-5H3,(H,34,38)/b19-12+/t27-,28-/m1/s1
PubChem CID10744738
ChEMBLCHEMBL122420
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC5024.0 nMPMID9733496ChEMBL
Emax115.0 %PMID9733496ChEMBL

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