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GPCR

NameD(1A) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd1
SynonymD1 receptor
D1A
DADR
dopamine D1 receptor
Dopamine-1A receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length446
Amino acid sequenceMAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
UniProtP18901
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL265
IUPHAR214
DrugBankN/A

Ligand

NameCHEMBL72220
Molecular formulaC21H23ClN2
IUPAC name1-(6-chloro-2-methyl-9-tricyclo[9.4.0.03,8]pentadeca-1(15),3(8),4,6,9,11,13-heptaenyl)-4-methylpiperazine
Molecular weight338.879
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP4.9
SynonymsBDBM50017518
1-(8-Chloro-5-methyl-5H-dibenzo[a,d]cyclohepten-10-yl)-4-methyl-piperazine
Inchi KeyASIRPKXJTMFOPA-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H23ClN2/c1-15-18-6-4-3-5-16(18)13-21(24-11-9-23(2)10-12-24)20-14-17(22)7-8-19(15)20/h3-8,13-15H,9-12H2,1-2H3
PubChem CID44312604
ChEMBLCHEMBL72220
IUPHARN/A
BindingDB50017518
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5074.0 nMPMID2571728BindingDB,ChEMBL

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