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GLASS

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GPCR

Name	Glucagon-like peptide 1 receptor
Species	Homo sapiens (Human)
Gene	GLP1R
Synonym	glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor
Disease	Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis Irritable bowel syndrome; Dyspepsia Unspecified Diabetes Brain injury Type 2 diabetes [ Show all ]
Length	463
Amino acid sequence	MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
UniProt	P43220
Protein Data Bank	5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv
GPCR-HGmod model	P43220
3D structure model	This structure is from PDB ID 5vex.
BioLiP	BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966
Therapeutic Target Database	T36075
ChEMBL	CHEMBL1784
IUPHAR	249
DrugBank	BE0000857

Ligand

Name	MLS000584180
Molecular formula	C18H15ClN2O2
IUPAC name	2-chloro-3-[4-(dimethylamino)anilino]naphthalene-1,4-dione
Molecular weight	326.78
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.3
Synonyms	2-chloro-3-{[4-(dimethylamino)phenyl]amino}naphthoquinone CHEMBL1451772 NCIOpen2_009955 1,4-Naphthalenedione,2-chloro-3-[[4-(dimethylamino)phenyl]amino]- AC1L63EB DTXSID90293767 SCHEMBL6501763 2-chloro-3-[4-(dimethylamino)anilino]naphthalene-1,4-dione BDBM34778 cid_260557 NSC-92081 2-chloranyl-3-[[4-(dimethylamino)phenyl]amino]naphthalene-1,4-dione AC1Q6B4H HMS2620L09 SMR000203343 2-chloro-3-{[4-(dimethylamino)phenyl]amino}-1,4-naphthoquinone MolPort-003-711-560 42262-96-4 CTK4I5957 NSC92081 2-chloro-3-[4-(dimethylamino)anilino]-1,4-naphthoquinone AKOS001569126 MCULE-5140727957 ZINC175659 [ Show all ]
Inchi Key	IFCBGAQTKDYXAL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H15ClN2O2/c1-21(2)12-9-7-11(8-10-12)20-16-15(19)17(22)13-5-3-4-6-14(13)18(16)23/h3-10,20H,1-2H3
PubChem CID	260557
ChEMBL	CHEMBL1451772
IUPHAR	N/A
BindingDB	34778
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	28183.8 nM	PubChem BioAssay data set	ChEMBL

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