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GPCR

NameGalanin receptor type 1
SpeciesHomo sapiens (Human)
GeneGALR1
SynonymGAL1-R
GALNR
GALNR1
GALR-1
GAL1 receptor
DiseaseEpileptic seizures
Length349
Amino acid sequenceMELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV
UniProtP47211
Protein Data BankN/A
GPCR-HGmod modelP47211
3D structure modelThis predicted structure model is from GPCR-EXP P47211.
BioLiPN/A
Therapeutic Target DatabaseT78581
ChEMBLCHEMBL4894
IUPHAR243
DrugBankN/A

Ligand

NameCHEMBL1922007
Molecular formulaC23H24F3N5O2
IUPAC name2-N-(4-methoxyphenyl)-6-piperidin-1-yl-4-N-[4-(trifluoromethoxy)phenyl]pyrimidine-2,4-diamine
Molecular weight459.473
Hydrogen bond acceptor10
Hydrogen bond donor2
XlogP6.4
SynonymsSCHEMBL10143575
BDBM50358677
Inchi KeyIEPZREPGCVYQOI-UHFFFAOYSA-N
Inchi IDInChI=1S/C23H24F3N5O2/c1-32-18-9-5-17(6-10-18)28-22-29-20(15-21(30-22)31-13-3-2-4-14-31)27-16-7-11-19(12-8-16)33-23(24,25)26/h5-12,15H,2-4,13-14H2,1H3,(H2,27,28,29,30)
PubChem CID54764411
ChEMBLCHEMBL1922007
IUPHARN/A
BindingDB50358677
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition60.0 %PMID22018787ChEMBL

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