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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	prazosin
Molecular formula	C19H21N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
Molecular weight	383.408
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	2.0
Synonyms	Vasoflex (TN) KBio3_000732 AB00053528 [3H]-Pratsiol Lentopres AN-18022 NCGC00016740-02 Bio2_000358 NCGC00016740-10 BSPBio_001036 NCGC00024324-02 CHEMBL2 NCI60_002417 Prazosine DivK1c_000375 Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-(9CI) Prestwick3_000947 GTPL503 (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone SPBio_001297 HSDB 3298 1-(4-amino-6,7-dimethoxy-2-quinazolinyl-4-(2-furanylcarbonyl)) piperrazine ST24038261 KBio1_000375 2-[4-(Furan-2-Ylcarbonyl)piperazin-1-Yl]-6,7-Dimethoxyquinazolin-4-Amine XRA KBioGR_000965 AB00053528_21 [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone Minipress BCP14556 NCGC00016740-05 BRD-K49111258-001-02-8 NCGC00016740-13 C19H21N5O4 NCGC00024324-06 Prazosin (INN) CTK7A0338 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- Prazosinum [INN-Latin] DSSTox_RID_83272 SBB032268 HMS1362D17 1-(3-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride Spectrum3_000551 IDI1_000375 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline TNP00312 KBio2_002944 KBio2_006438 [3H]-Furazosin KS-00002WRN AKOS000310009 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone MolPort-000-891-036 Bio1_000854 NCGC00016740-08 BRN 0768345 NCGC00016740-18 CHEBI:8364 NCGC00024324-09 Prazosina Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI) Prestwick1_000947 FT-0630457 SMP1_000063 HMS2089G09 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine Spectrum_000822 Justac 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine Tox21_113646_1 W-107722 KBio3_001721 AB00053528-19 [3H]-Prazosin LS-140002 BBL028799 NCGC00016740-03 Bio2_000838 NCGC00016740-11 BSPBio_002221 NCGC00024324-04 CP-12299 NINDS_000375 Prazosine [INN-French] DSSTox_CID_29008 Prazocin Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)- GTPL5385 SPBio_003073 HY-B0193 19216-56-9 STK301545 KBio2_000376 2-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone Z275127478 KBioSS_000376 AC1L1J6T [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone Minipress (TN) BDBM29568 NCGC00016740-06 BRD-K49111258-003-05-7 NCGC00016740-14 CAS-19216-56-9 NCGC00024324-07 Prazosin [INN:BAN] D08411 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI) Pressin DTXSID4049082 SBI-0051487.P003 HMS1792D17 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine Spectrum4_000483 IDI1_002113 2-[4-(2-Furoyl)-1-piperazinyl]-6,7-dimethoxy-4-quinazolinamine # Tocris-0623 KBio2_003870 UNII-XM03YJ541D KBio3_000731 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)piperazin-1-yl]quinazoline [3H]-Minipress L000666 AN-15618 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-furan-2-ylmethanone NCGC00016740-01 Bio1_001343 NCGC00016740-09 BSPBio_000914 NCGC00016740-19 NCGC00024324-10 Prazosina [INN-Spanish] DB00457 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-(8CI) Prestwick2_000947 Furazosin (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-piperazin-1-yl)(furan-2-yl)methanone SMR001550197 HMS3403D17 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-(2-furoyl)piperazine ST075549 KB-207710 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine XM03YJ541D KBioGR_000376 AB00053528_20 [3H]prazosin MCULE-8104643269 BCBcMAP01_000227 NCGC00016740-04 BPBio1_001006 NCGC00016740-12 C07368 NCGC00024324-05 CS-2088 Oprea1_314778 Prazosinum DSSTox_GSID_49082 SB17351 H961 1-(3-Amino-6,7-dimethoxy-2- quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride Spectrum2_001289 Hypovase (TN) 2-(4-(2-FUROYL)-1-PIPERAZINYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE TL8001573 KBio2_001302 237P844 5-25-13-00365 (Beilstein Handbook Reference) ZINC95616601 KBioSS_001302 AF-0052 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone MLS006011888 Bio1_000365 NCGC00016740-07 BRD-K49111258-003-16-4 NCGC00016740-15 CAS-19237-84-4 NCGC00024324-08 PRAZOSIN, Prazosin Hydrochloride D0WV3U Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- Prestwick0_000947 EINECS 242-885-8 SCHEMBL26524 HMS1990D17 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine Spectrum5_001365 IENZQIKPVFGBNW-UHFFFAOYSA-N 2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline Tox21_113646 KBio2_005512 [ Show all ]
Inchi Key	IENZQIKPVFGBNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
PubChem CID	4893
ChEMBL	CHEMBL2
IUPHAR	503
BindingDB	29568
DrugBank	DB00457
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	5.4 nM	PMID1656026	BindingDB
Ki	11.6 nM	PMID1353247	BindingDB

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