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GPCR

Name	Alpha-2B adrenergic receptor
Species	Didelphis virginiana (North American opossum)
Gene	ADRA2B
Synonym	Alpha-2B adrenoceptor Alpha-2B adrenoreceptor Alpha-2BAR
Disease	N/A for non-human GPCRs
Length	382
Amino acid sequence	AIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRHTWCEVYLALDVLFCTSSIVHLCAISLDRYWSVSRALEYNSKRTPRRIKGIILTVWLIAAFISLPPLIYKGDKGKKPGGRPQCKLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLIAKRRNRQGPHGKQAPGDGDTGPSALGGTSTISKLPPSILPAVGEANGHSKPPGEREGGEQMGDPTSPSTPPNQSSVGPEDGSQKQEEEEEEEEEEEEECGPPAPPTSSSLQGTPNFQPSQGSQVLATLRGQVLLARGPASLGLQPWRRRTQMNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPQHCKVPHGLF
UniProt	O77715
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	N/A
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	prazosin
Molecular formula	C19H21N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
Molecular weight	383.408
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	2.0
Synonyms	KBio1_000375 2-[4-(Furan-2-Ylcarbonyl)piperazin-1-Yl]-6,7-Dimethoxyquinazolin-4-Amine KBio3_000732 AB00053528 Lentopres Prazosinum AN-18022 NCGC00016740-02 SB17351 Bio2_000358 NCGC00016740-10 Spectrum2_001289 BSPBio_001036 NCGC00024324-02 TL8001573 CHEMBL2 NCI60_002417 XM03YJ541D DivK1c_000375 Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-(9CI) [3H]prazosin GTPL503 (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone HSDB 3298 1-(4-amino-6,7-dimethoxy-2-quinazolinyl-4-(2-furanylcarbonyl)) piperrazine 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline KBio2_002944 KBioGR_000965 PRAZOSIN, Prazosin Hydrochloride AB00053528_21 Minipress Prestwick0_000947 BCP14556 NCGC00016740-05 SCHEMBL26524 BRD-K49111258-001-02-8 NCGC00016740-13 Spectrum5_001365 C19H21N5O4 NCGC00024324-06 Tox21_113646 CTK7A0338 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- ZINC95616601 DSSTox_RID_83272 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone HMS1362D17 1-(3-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride IDI1_000375 Justac 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine KBio2_006438 KS-00002WRN Prazosine AKOS000310009 MolPort-000-891-036 Prestwick3_000947 Bio1_000854 NCGC00016740-08 SPBio_001297 BRN 0768345 NCGC00016740-18 ST24038261 CHEBI:8364 NCGC00024324-09 Vasoflex (TN) Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI) [3H]-Pratsiol FT-0630457 HMS2089G09 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine KBio2_000376 2-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine KBio3_001721 Prazosin (INN) AB00053528-19 LS-140002 Prazosinum [INN-Latin] BBL028799 NCGC00016740-03 SBB032268 Bio2_000838 NCGC00016740-11 Spectrum3_000551 BSPBio_002221 NCGC00024324-04 TNP00312 CP-12299 NINDS_000375 XRA DSSTox_CID_29008 Prazocin [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone GTPL5385 HY-B0193 19216-56-9 2-[4-(2-Furoyl)-1-piperazinyl]-6,7-dimethoxy-4-quinazolinamine # KBio2_003870 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone KBioSS_000376 Prazosina AC1L1J6T Minipress (TN) Prestwick1_000947 BDBM29568 NCGC00016740-06 SMP1_000063 BRD-K49111258-003-05-7 NCGC00016740-14 Spectrum_000822 CAS-19216-56-9 NCGC00024324-07 Tox21_113646_1 D08411 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI) [3H]-Furazosin DTXSID4049082 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone HMS1792D17 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine IDI1_002113 KB-207710 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine KBio3_000731 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)piperazin-1-yl]quinazoline L000666 Prazosine [INN-French] AN-15618 NCGC00016740-01 Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)- Bio1_001343 NCGC00016740-09 SPBio_003073 BSPBio_000914 NCGC00016740-19 STK301545 NCGC00024324-10 W-107722 DB00457 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-(8CI) [3H]-Prazosin Furazosin (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-piperazin-1-yl)(furan-2-yl)methanone HMS3403D17 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-(2-furoyl)piperazine 2-(4-(2-FUROYL)-1-PIPERAZINYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE KBio2_001302 237P844 KBioGR_000376 Prazosin [INN:BAN] AB00053528_20 MCULE-8104643269 Pressin BCBcMAP01_000227 NCGC00016740-04 SBI-0051487.P003 BPBio1_001006 NCGC00016740-12 Spectrum4_000483 C07368 NCGC00024324-05 Tocris-0623 CS-2088 Oprea1_314778 Z275127478 DSSTox_GSID_49082 [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone H961 1-(3-Amino-6,7-dimethoxy-2- quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride Hypovase (TN) 2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline KBio2_005512 5-25-13-00365 (Beilstein Handbook Reference) KBioSS_001302 Prazosina [INN-Spanish] AF-0052 MLS006011888 Prestwick2_000947 Bio1_000365 NCGC00016740-07 SMR001550197 BRD-K49111258-003-16-4 NCGC00016740-15 ST075549 CAS-19237-84-4 NCGC00024324-08 UNII-XM03YJ541D D0WV3U Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- [3H]-Minipress EINECS 242-885-8 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-furan-2-ylmethanone HMS1990D17 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine IENZQIKPVFGBNW-UHFFFAOYSA-N [ Show all ]
Inchi Key	IENZQIKPVFGBNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
PubChem CID	4893
ChEMBL	CHEMBL2
IUPHAR	503
BindingDB	29568
DrugBank	DB00457
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.4 nM	PMID2894455	BindingDB
Ki	7.6 nM	PMID2894455	BindingDB
Ki	117.48 nM	PMID7908054	BindingDB
Ki	131.82 nM	PMID7908054	BindingDB

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