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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL61879
Molecular formula	C16H13F3N2O
IUPAC name	N-(9-ethylcarbazol-3-yl)-2,2,2-trifluoroacetamide
Molecular weight	306.288
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.9
Synonyms	STK181949 AB00112892-01 MolPort-002-213-160 N-(9-ethylcarbazol-3-yl)-2,2,2-trifluoroacetamide ASFXOPCVODXQIM-UHFFFAOYSA-N ZINC2874023 3-(Trifluoroacetylamino)-9-ethyl-9H-carbazole AC1M2V26 N-(9-Ethyl-9H-carbazol-3-yl)-2,2,2-trifluoro-acetamide SCHEMBL1044958 BDBM50128929 MCULE-2855480120 N-(9-ethyl-9H-carbazol-3-yl)-2,2,2-trifluoroacetamide AKOS003239191 [ Show all ]
Inchi Key	ASFXOPCVODXQIM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H13F3N2O/c1-2-21-13-6-4-3-5-11(13)12-9-10(7-8-14(12)21)20-15(22)16(17,18)19/h3-9H,2H2,1H3,(H,20,22)
PubChem CID	2226619
ChEMBL	CHEMBL61879
IUPHAR	N/A
BindingDB	50128929
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	14.0 nM	PMID12781180	BindingDB,ChEMBL

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