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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M3
Species	Mus musculus (Mouse)
Gene	Chrm3
Synonym	cholinergic receptor, muscarinic 3 cholinergic receptor, muscarinic 3, cardiac Chrm-3 cholinergic receptor M3 receptor M3R Mm3 mAChR HM4 [ Show all ]
Disease	N/A for non-human GPCRs
Length	589
Amino acid sequence	MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVSQLDSYNISQTSGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGTKRSSRRKYGGCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPDKDLGTMDVERNAHKLQAQKSMDDRDNCQKDFSKLPIQLESAVDTAKTSDTNSSVDKTTAALPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProt	Q9ERZ3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5105
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	158142-45-1
Molecular formula	C6H10N2O2
IUPAC name	methyl 1,4,5,6-tetrahydropyrimidine-5-carboxylate
Molecular weight	142.158
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	-0.9
Synonyms	AKOS006358308 CHEMBL538467 1,4,5,6-Tetrahydro-5-pyrimidinecarboxylic acid methyl ester Methyl 1,4,5,6-tetrahydropyrimidine-5-carboxylate 5-pyrimidinecarboxylic acid,1,4,5,6-tetrahydro-,methyl ester BDBM50039839 KB-198515 1,4,5,6-Tetrahydro-pyrimidine-5-carboxylic acid methyl ester; hydrochloride SCHEMBL8306627 CHEMBL1189286 L008012 [ Show all ]
Inchi Key	ASEICNBZJHLFCN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C6H10N2O2/c1-10-6(9)5-2-7-4-8-3-5/h4-5H,2-3H2,1H3,(H,7,8)
PubChem CID	10197743
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50039839
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	50000.0 nM	PMID9111297	BindingDB

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