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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL203166
Molecular formula	C28H30F4N4O2
IUPAC name	1-[(1R,3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-3-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[2-[(3S)-3-hydroxypyrrolidin-1-yl]ethyl]urea
Molecular weight	530.568
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	4.6
Synonyms	6-(3-cyano-phenyl)-bicyclo[4.1.0]hept-3-yl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[2-((S)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea BDBM50184933
Inchi Key	IDIPINAYGICHHM-ONLLFZDPSA-N
Inchi ID	InChI=1S/C28H30F4N4O2/c29-25-5-4-21(14-24(25)28(30,31)32)34-26(38)36(11-10-35-9-7-23(37)17-35)22-6-8-27(15-20(27)13-22)19-3-1-2-18(12-19)16-33/h1-5,12,14,20,22-23,37H,6-11,13,15,17H2,(H,34,38)/t20-,22+,23-,27+/m0/s1
PubChem CID	44409527
ChEMBL	CHEMBL203166
IUPHAR	N/A
BindingDB	50184933
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Kb	11.0 nM	PMID16570926	ChEMBL
Ki	15.1 nM	PMID16570926	BindingDB,ChEMBL

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