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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 2
Species	Homo sapiens (Human)
Gene	MCHR2
Synonym	G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor MCH2 G protein-coupled receptor 145 MCH-2R MCH receptor 2 GPRv17 GPR145 MCH-R2 [ Show all ]
Disease	N/A
Length	340
Amino acid sequence	MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProt	Q969V1
Protein Data Bank	N/A
GPCR-HGmod model	Q969V1
3D structure model	This predicted structure model is from GPCR-EXP Q969V1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5038
IUPHAR	281
DrugBank	N/A

Ligand

Name	CHEMBL386509
Molecular formula	C21H20F3N3O
IUPAC name	N-(4-amino-2-propylquinolin-6-yl)-2-[4-(trifluoromethyl)phenyl]acetamide
Molecular weight	387.406
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.4
Synonyms	BDBM50193633 N-(4-amino-2-propylquinolin-6-yl)-2-(4-(trifluoromethyl)phenyl)acetamide
Inchi Key	IDFBMMGOBKDDRJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H20F3N3O/c1-2-3-15-12-18(25)17-11-16(8-9-19(17)26-15)27-20(28)10-13-4-6-14(7-5-13)21(22,23)24/h4-9,11-12H,2-3,10H2,1H3,(H2,25,26)(H,27,28)
PubChem CID	44417824
ChEMBL	CHEMBL386509
IUPHAR	N/A
BindingDB	50193633
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>50.0 %	PMID16919453	ChEMBL

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