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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL1077578
Molecular formula	C17H19NO2S
IUPAC name	7-(benzenesulfonylmethyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
Molecular weight	301.404
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.5
Synonyms	BDBM50415667 ICKFLQAGATZMFM-UHFFFAOYSA-N SCHEMBL1789401 7-(phenylsulfonylmethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine
Inchi Key	ICKFLQAGATZMFM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19NO2S/c19-21(20,17-4-2-1-3-5-17)13-14-6-7-15-8-10-18-11-9-16(15)12-14/h1-7,12,18H,8-11,13H2
PubChem CID	46882673
ChEMBL	CHEMBL1077578
IUPHAR	N/A
BindingDB	50415667
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<10000.0 nM	PMID19804969	BindingDB,ChEMBL

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