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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 7b
Species	Rattus norvegicus (Rat)
Gene	Taar7b
Synonym	TaR-12 TaR-7b Trace amine receptor 12 Trace amine receptor 7b
Disease	N/A for non-human GPCRs
Length	358
Amino acid sequence	MATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProt	Q923X8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2176813
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3701910
Molecular formula	C16H16F3N3O
IUPAC name	N-(4-morpholin-2-ylphenyl)-5-(trifluoromethyl)pyridin-2-amine
Molecular weight	323.319
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	2.6
Synonyms	US8802673, 11 BDBM129369 SCHEMBL12609727
Inchi Key	ICJRJBTWDCPIOM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H16F3N3O/c17-16(18,19)12-3-6-15(21-9-12)22-13-4-1-11(2-5-13)14-10-20-7-8-23-14/h1-6,9,14,20H,7-8,10H2,(H,21,22)
PubChem CID	68325509
ChEMBL	CHEMBL3701910
IUPHAR	N/A
BindingDB	129369
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	23.3 nM	, None	BindingDB,ChEMBL

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