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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Metabotropic glutamate receptor 7
Species	Rattus norvegicus (Rat)
Gene	Grm7
Synonym	GLUR7 glutamate receptor GPRC1G mGlu7 receptor mGlu7a receptor mGluR7 [ Show all ]
Disease	N/A for non-human GPCRs
Length	915
Amino acid sequence	MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIFQYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNSPAAKKKYVSYNNLVI
UniProt	P35400
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3879
IUPHAR	295
DrugBank	N/A

Ligand

Name	L-PHOSPHINOTHRICIN
Molecular formula	C5H12NO4P
IUPAC name	(2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid
Molecular weight	181.128
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-5.0
Synonyms	1fpy Phosphinothricine IAJOBQBIJHVGMQ-BYPYZUCNSA-N UNII-72P470U27C (S)-2-Amino-4-(hydroxy-methyl-phosphinoyl)-butyric acid; hydrochloride BDBM50174527 L-homoalanin-4-yl(methyl)phosphinic acid 2-AMINO-4-(HYDROXYMETHYL-PHOSPHINYL)BUTANOIC ACID CHEMBL145114 PPQ 72P470U27C L-2-Amino-4-(hydroxymethylphosphinyl)butanoate UNII-C8W4FP6BTY component IAJOBQBIJHVGMQ-BYPYZUCNSA-N (S)-Phosphinothricin@CRLF35597-44-5 C04650 35597-44-5 CHEMBL535153 SCHEMBL21986 (2S)-2-amino-4-[hydroxy(methyl)phosphoryl]butanoic acid AC1L3MFS L-Glufosinate ZINC902209 [ Show all ]
Inchi Key	IAJOBQBIJHVGMQ-BYPYZUCNSA-N
Inchi ID	InChI=1S/C5H12NO4P/c1-11(9,10)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10)/t4-/m0/s1
PubChem CID	91619
ChEMBL	CHEMBL145114
IUPHAR	N/A
BindingDB	50174527
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<500000.0 nM	PMID17722902	BindingDB,ChEMBL

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