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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2a
Synonym	CA2-47 alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2D adrenergic receptor Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P22909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL327
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine
Molecular formula	C10H11Cl2N
IUPAC name	8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine
Molecular weight	216.105
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.9
Synonyms	LY1 8,9-dichloro-2,3,4,5-tetrahydro-1H-[2]benzazepine DB04273 tetrahydrobenzazepine (THBA) deriv. 1n7i AKOS023600776 LY 134046 8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine hydrochloride CHEMBL38681 LY134046 AC1L3TOS GTPL6631 71274-97-0 BDBM14061 LY-134046 8,9-DICHLORO-2,3,4,5-TETRAHYDRO-1H-BENZO[C]AZEPINE D05ZKW SCHEMBL476330 1H-2-Benzazepine, 8,9-dichloro-2,3,4,5-tetrahydro- AC1Q3LGA Lilly 134046 [ Show all ]
Inchi Key	IADAQXMUWITWNG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H11Cl2N/c11-9-4-3-7-2-1-5-13-6-8(7)10(9)12/h3-4,13H,1-2,5-6H2
PubChem CID	121938
ChEMBL	CHEMBL38681
IUPHAR	N/A
BindingDB	14061
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4500.0 nM	PMID14695818	BindingDB,ChEMBL

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