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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL49921
Molecular formula	C28H39N3O3
IUPAC name	1-(3-acetylphenyl)-3-[3-[(2R,4S)-4-benzyl-2-[(1S)-1-hydroxybutyl]piperidin-1-yl]propyl]urea
Molecular weight	465.638
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	4.4
Synonyms	BDBM50115084 1-(3-Acetyl-phenyl)-3-{3-[(2R,4S)-4-benzyl-2-((S)-1-hydroxy-butyl)-piperidin-1-yl]-propyl}-urea
Inchi Key	ARPXRILPIHWQDL-MVNQZMKCSA-N
Inchi ID	InChI=1S/C28H39N3O3/c1-3-9-27(33)26-19-23(18-22-10-5-4-6-11-22)14-17-31(26)16-8-15-29-28(34)30-25-13-7-12-24(20-25)21(2)32/h4-7,10-13,20,23,26-27,33H,3,8-9,14-19H2,1-2H3,(H2,29,30,34)/t23-,26-,27+/m1/s1
PubChem CID	44295591
ChEMBL	CHEMBL49921
IUPHAR	N/A
BindingDB	50115084
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7.0 nM	PMID12067561	ChEMBL
IC50	7.0 nM	PMID12067561	BindingDB

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