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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL596154
Molecular formulaC15H22ClNO
IUPAC name(2S)-N-tert-butyl-2-(4-chlorophenyl)-3-methylbutanamide
Molecular weight267.797
Hydrogen bond acceptor1
Hydrogen bond donor1
XlogP4.1
SynonymsBDBM50305944
(S)-N-tert-butyl-2-(4-chlorophenyl)-3-methylbutanamide
Inchi KeyHXRDPRMNITUMNC-ZDUSSCGKSA-N
Inchi IDInChI=1S/C15H22ClNO/c1-10(2)13(14(18)17-15(3,4)5)11-6-8-12(16)9-7-11/h6-10,13H,1-5H3,(H,17,18)/t13-/m0/s1
PubChem CID46226107
ChEMBLCHEMBL596154
IUPHARN/A
BindingDB50305944
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy>30.0 %PMID20005104ChEMBL
IC50<100000.0 nMPMID20005104BindingDB,ChEMBL

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