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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh2
Synonym	gastric receptor I H2 receptor H2R HH2R
Disease	N/A for non-human GPCRs
Length	358
Amino acid sequence	MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
UniProt	P25102
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4654
IUPHAR	263
DrugBank	N/A

Ligand

Name	BURIMAMIDE
Molecular formula	C9H16N4S
IUPAC name	1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea
Molecular weight	212.315
Hydrogen bond acceptor	2
Hydrogen bond donor	3
XlogP	0.4
Synonyms	HXRBAVXGYZUSED-UHFFFAOYSA-N SCHEMBL7860369 AC1MHUYH C07448 N-(4-imidazol-4-ylbutyl)-N'-methylthiourea UNII-TN5A4OD2TV CHEMBL12160 PDSP1_001097 LS-187038 Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl- BDBM22888 CHEBI:3221 N-methyl-N'-[4-(4-imidazolyl)butyl]thiourea ZINC13831238 1-[4-(1H-imidazol-5-yl)butyl]-3-methyl-thiourea DTXSID00188519 PDSP2_001081 34970-69-9 LS-187654 TN5A4OD2TV NCGC00167790-01 1-[4-(1H-imidazol-5-yl)butyl]-3-methylthiourea [ Show all ]
Inchi Key	HXRBAVXGYZUSED-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H16N4S/c1-10-9(14)12-5-3-2-4-8-6-11-7-13-8/h6-7H,2-5H2,1H3,(H,11,13)(H2,10,12,14)
PubChem CID	3032915
ChEMBL	CHEMBL12160
IUPHAR	N/A
BindingDB	22888
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kb	6600.0 nM	PMID17751	ChEMBL

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