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Name | Glucose-dependent insulinotropic receptor |
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Species | Homo sapiens (Human) |
Gene | GPR119 |
Synonym | GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 [ Show all ] |
Disease | Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes |
Length | 335 |
Amino acid sequence | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG |
UniProt | Q8TDV5 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q8TDV5 |
3D structure model | This predicted structure model is from GPCR-EXP Q8TDV5. |
BioLiP | N/A |
Therapeutic Target Database | T93788 |
ChEMBL | CHEMBL5652 |
IUPHAR | 126 |
DrugBank | N/A |
Name | CHEMBL1773294 |
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Molecular formula | C21H24N4O6S |
IUPAC name | propan-2-yl 4-[[3-(4-methylsulfonylphenyl)-[1,2]oxazolo[4,5-d]pyrimidin-7-yl]oxy]piperidine-1-carboxylate |
Molecular weight | 460.505 |
Hydrogen bond acceptor | 9 |
Hydrogen bond donor | 0 |
XlogP | 2.5 |
Synonyms | SCHEMBL388346 BDBM50343458 isopropyl 4-(3-(4-(methylsulfonyl)phenyl)isoxazolo[4,5-d]pyrimidin-7-yloxy)piperidine-1-carboxylate |
Inchi Key | HUDHXIUFUNEPFV-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H24N4O6S/c1-13(2)29-21(26)25-10-8-15(9-11-25)30-20-19-18(22-12-23-20)17(24-31-19)14-4-6-16(7-5-14)32(3,27)28/h4-7,12-13,15H,8-11H2,1-3H3 |
PubChem CID | 11271133 |
ChEMBL | CHEMBL1773294 |
IUPHAR | N/A |
BindingDB | 50343458 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 14.0 nM | PMID21444206 | BindingDB,ChEMBL |
Emax | 65.0 % | PMID21444206 | ChEMBL |
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