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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H1 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh1
Synonym	H1 receptor H1R HH1R Hisr
Disease	N/A for non-human GPCRs
Length	486
Amino acid sequence	MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
UniProt	P31390
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4701
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	METHDILAZINE
Molecular formula	C18H20N2S
IUPAC name	10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine
Molecular weight	296.432
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.2
Synonyms	10H-Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)- BDBM81470 GTPL7231 Methdilazinum NSC-244191 Product 5022 1229-35-2 (hydrochloride) CAS_14677 Disyncram LS-979 Methodilazine NSC_14677 SR-01000944494-1 10-((1-Methyl-3-pyrrolidinyl)methyl)phenothiazine 10-[(1-methylpyrrolidin-3-yl)methyl]-10H-phenothiazine AC1L24C6 D04979 DTXSID6023282 Methdilazine [USAN:INN:BAN] NCI-C60720 Phenothiazine, 10-((1-methyl-3-pyrrolidinyl)methyl)- Tacazyl 10H-Phenothiazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]- C07175 DB00902 HTMIBDQKFHUPSX-UHFFFAOYSA-N Methdilazinum [INN-Latin] NSC169091 SCHEMBL121507 1982-37-2 CHEBI:6823 Disyncram (Salt/Mix) Metodilazina PDSP1_000149 Tacaryl 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine # 10-[(1-Methylpyrrolidin-3-yl)methyl]phenothiazine AC1Q7G4W D0LR0R EINECS 217-841-6 Methdilazine [USP:INN:BAN] NCI60_001351 Phenothiazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]- Tacryl 10H-Phenothiazine, tannate (5:1) C18H20N2S Dilosyn (Salt/Mix) L001130 Methilazine hydrochloride NSC244191 SR-01000944494 10-((1-methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine 10-[(1-Methyl-3-Pyrrolidinyl)methyl]phenothiazine CHEMBL1200959 Disyncran (Salt/Mix) Methdilazine (INN) Metodilazina [INN-Spanish] PDSP2_000148 Tacaryl (TN) [ Show all ]
Inchi Key	HTMIBDQKFHUPSX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3
PubChem CID	14677
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81470
DrugBank	DB00902
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2.3 nM	PMID282646	BindingDB

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