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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2B adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2b
Synonym	ADRA2L1 alpha2B-adrenoceptor alpha2B alpha2-C2 alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor Adra-2b adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 alpha-2B adrenergic receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	453
Amino acid sequence	MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAEEGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
UniProt	P19328
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL266
IUPHAR	26
DrugBank	N/A

Ligand

Name	Atipamezole
Molecular formula	C14H16N2
IUPAC name	5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole
Molecular weight	212.296
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.0
Synonyms	AN-14783 Atipamezole [USAN:BAN:INN] BDBM81807 D03002 HY-12380A MPV 1248 PDSP2_001566 SR-01000944943-1 1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)- Antisedan (TN) Atipamezole; MPV-1248 CAS_104054-27-5 DSSTox_GSID_49135 KB-47451 NCGC00182707-01 s4650 UNII-03N9U5JAF6 4-(2-Ethyl-2-indanyl)imidazole AC1L2FXQ AKOS015900246 BC226060 CS-3390 EBD30510 MFCD00864502 NSC_71310 SCHEMBL304971 104054-27-5 ZINC5424171 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole antipamezole Atipamezole [USAN:INN:BAN] C14H16N2 D05OVC I14-1027 MPV-1248 PubChem21912 Tox21_113005 308081-08-5 A26271 Atipamezol Atipamezolum DSSTox_RID_83274 L000823 NCGC00182707-02 SC-21403 03N9U5JAF6 Zeolite, type: ZSM-5 4-(2-ethyl-2-indanyl)imidazole; 4-(2-ethyl-2,3-dihydro-1h-inden-2-yl)-1h-imidazole AC1Q4WOE AKOS032960366 Atipamezole (USAN/INN) BCP02215 CTK4A2660 FT-0603697 MolPort-042-652-814 PDSP1_001582 SR-01000944943 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)- 5-(2-ethylindan-2-yl)-1H-imidazole Antisedan Atipamezole, >=98% (HPLC) CAS-104054-27-5 DSSTox_CID_29061 J-513300 MPV1248 RL00197 Tox21_113005_1 4-(2-ethyl-2,3-dihydro-1h-inden-2-yl)-1h-imidazole AC-1614 ACMC-20bb9y Atipamezol [Spanish] Atipamezolum [Latin] CHEMBL353972 DTXSID2049135 LS-171901 NCGC00182707-03 SC-27035 054A275 Zeolite,type: ZSM-5 5-(2-ethyl-1,3-dihydroinden-2-yl)-1H-imidazole [ Show all ]
Inchi Key	HSWPZIDYAHLZDD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N2/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14/h3-6,9-10H,2,7-8H2,1H3,(H,15,16)
PubChem CID	71310
ChEMBL	CHEMBL353972
IUPHAR	N/A
BindingDB	81807
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.68 nM	PMID1656026	BindingDB

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