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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	CHEMBL384698
Molecular formula	C31H42N4O4
IUPAC name	(5R,8R,11S,16Z)-5-[(4-hydroxyphenyl)methyl]-8-propan-2-yl-11-propyl-4,7,10,13-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-6,9,12-trione
Molecular weight	534.701
Hydrogen bond acceptor	5
Hydrogen bond donor	5
XlogP	4.9
Synonyms	BDBM50199379 (E/Z)-(8R,11R,14S)-8-(4-hydroxy-benzyl)-11-isopropyl-14-propyl-5,7,8,10,11,13,14,16,17,18-decahydro-6H-7,10,13,16-tetraaza-benzocyclooctadecene-9,12,15-trione
Inchi Key	HPCVAFISJXNTEA-XVYFQXMKSA-N
Inchi ID	InChI=1S/C31H42N4O4/c1-4-9-26-29(37)33-18-8-7-12-23-10-5-6-11-24(23)17-19-32-27(20-22-13-15-25(36)16-14-22)30(38)35-28(21(2)3)31(39)34-26/h5-7,10-16,21,26-28,32,36H,4,8-9,17-20H2,1-3H3,(H,33,37)(H,34,39)(H,35,38)/b12-7-/t26-,27+,28+/m0/s1
PubChem CID	44417758
ChEMBL	CHEMBL384698
IUPHAR	N/A
BindingDB	50199379
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<10000.0 nM	PMID17125271	BindingDB,ChEMBL

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