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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL1909718
Molecular formula	C16H24N4O2S2
IUPAC name	N-[5-[(4-pyridin-3-yl-1,3-thiazol-2-yl)amino]pentyl]propane-2-sulfonamide
Molecular weight	368.514
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	2.8
Synonyms	BDBM50355845
Inchi Key	AQRWIECSMCJORF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H24N4O2S2/c1-13(2)24(21,22)19-10-5-3-4-9-18-16-20-15(12-23-16)14-7-6-8-17-11-14/h6-8,11-13,19H,3-5,9-10H2,1-2H3,(H,18,20)
PubChem CID	57403234
ChEMBL	CHEMBL1909718
IUPHAR	N/A
BindingDB	50355845
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	515.0 nM	PMID21924902	BindingDB,ChEMBL

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