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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	SCHEMBL1704149
Molecular formula	C25H32ClFN4O
IUPAC name	2-[3-chloro-4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]-1-[4-(3-fluoroanilino)piperidin-1-yl]ethanone
Molecular weight	459.006
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.9
Synonyms	CHEMBL2364290
Inchi Key	HOTLFLYDODUURG-SFHVURJKSA-N
Inchi ID	InChI=1S/C25H32ClFN4O/c1-18-16-30(12-9-28-18)17-20-6-5-19(13-24(20)26)14-25(32)31-10-7-22(8-11-31)29-23-4-2-3-21(27)15-23/h2-6,13,15,18,22,28-29H,7-12,14,16-17H2,1H3/t18-/m0/s1
PubChem CID	57586303
ChEMBL	CHEMBL2364290
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	5.012 nM	DOI: http://dx.doi.org/10.6019/CHEMBL2364262	ChEMBL

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