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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesHomo sapiens (Human)
GeneHTR7
Synonym5-HT-7
Serotonin receptor 7
5-HT-X
5-HT1Y
5-HT7
[ Show all ]
DiseaseSleep disorders
Schizophrenia
Major depressive disorder
Length479
Amino acid sequenceMMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProtP34969
Protein Data BankN/A
GPCR-HGmod modelP34969
3D structure modelThis predicted structure model is from GPCR-EXP P34969.
BioLiPN/A
Therapeutic Target DatabaseT79062
ChEMBLCHEMBL3155
IUPHAR12
DrugBankBE0000650, BE0004862

Ligand

NameCHEMBL305526
Molecular formulaC27H31N3O
IUPAC name2a-[4-(9-methyl-3,4-dihydro-1H-pyrido[3,4-b]indol-2-yl)butyl]-1,3,4,5-tetrahydrobenzo[cd]indol-2-one
Molecular weight413.565
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.3
SynonymsSCHEMBL6423921
Inchi KeyAQPAEUIJRBRZNA-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H31N3O/c1-29-23-12-3-2-10-20(23)21-13-17-30(18-24(21)29)16-5-4-14-27-15-7-9-19-8-6-11-22(25(19)27)28-26(27)31/h2-3,6,8,10-12H,4-5,7,9,13-18H2,1H3,(H,28,31)
PubChem CID11101733
ChEMBLCHEMBL305526
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki19.05 nMPMID12014957ChEMBL

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