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GPCR

NameGrowth hormone secretagogue receptor type 1
SpeciesHomo sapiens (Human)
GeneGHSR
Synonymghrelin receptor
GH-releasing peptide receptor
GHRP
GHS-R
growth hormone-releasing peptide receptor
[ Show all ]
DiseaseN/A
Length366
Amino acid sequenceMWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProtQ92847
Protein Data BankN/A
GPCR-HGmod modelQ92847
3D structure modelThis predicted structure model is from GPCR-EXP Q92847.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4616
IUPHAR246
DrugBankBE0003383

Ligand

NameCHEMBL238155
Molecular formulaC23H28N6O2
IUPAC name2-amino-2-methyl-N-[(1S)-2-phenylmethoxy-1-[1-[(E)-3-phenylprop-2-enyl]tetrazol-5-yl]ethyl]propanamide
Molecular weight420.517
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.0
SynonymsBDBM50222142
(S,E)-2-amino-N-(2-(benzyloxy)-1-(1-cinnamyl-1H-tetrazol-5-yl)ethyl)-2-methylpropanamide
Inchi KeyHLENXMZVAHVDRD-CBHXRGPZSA-N
Inchi IDInChI=1S/C23H28N6O2/c1-23(2,24)22(30)25-20(17-31-16-19-12-7-4-8-13-19)21-26-27-28-29(21)15-9-14-18-10-5-3-6-11-18/h3-14,20H,15-17,24H2,1-2H3,(H,25,30)/b14-9+/t20-/m1/s1
PubChem CID44434083
ChEMBLCHEMBL238155
IUPHARN/A
BindingDB50222142
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5012.0 nMPMID17869100BindingDB,ChEMBL
Ki190.0 nMPMID17869100BindingDB,ChEMBL

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