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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Urotensin-2 receptor
Species	Rattus norvegicus (Rat)
Gene	Uts2r
Synonym	UT receptor urotensin II receptor UR-II-R UR-2-R UII-R1 SENR (sensory epithelial neuropeptide-like receptor) SENR GPR14 G-protein coupled sensory epithelial neuropeptide-like receptor G-protein coupled receptor 14 G protein-coupled receptor 14 UTR2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	386
Amino acid sequence	MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
UniProt	P49684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4921
IUPHAR	365
DrugBank	N/A

Ligand

Name	CHEMBL237878
Molecular formula	C29H31N3O3
IUPAC name	N-benzyl-1-[2-(3-oxo-1,4-benzoxazin-4-yl)ethyl]-4-phenylpiperidine-4-carboxamide
Molecular weight	469.585
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.8
Synonyms	SCHEMBL4430260 BDBM50224726 N-benzyl-1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)ethyl)-4-phenylpiperidine-4-carboxamide
Inchi Key	HIJDWSULTFPAHX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H31N3O3/c33-27-22-35-26-14-8-7-13-25(26)32(27)20-19-31-17-15-29(16-18-31,24-11-5-2-6-12-24)28(34)30-21-23-9-3-1-4-10-23/h1-14H,15-22H2,(H,30,34)
PubChem CID	24803167
ChEMBL	CHEMBL237878
IUPHAR	N/A
BindingDB	50224726
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	43000.0 nM	PMID17933531	BindingDB,ChEMBL

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