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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameCHEMBL208081
Molecular formulaC29H29F2N3O3S
IUPAC name4-[4-(3-cyanophenyl)phenyl]-N-(3,4-difluorophenyl)-4-(1-methylsulfonylpiperidin-4-yl)butanamide
Molecular weight537.626
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP4.7
SynonymsBDBM50186781
4-(3''-cyano-biphenyl-4-yl)-N-(3,4-difluoro-phenyl)-4-(1-methanesulfonyl-piperidin-4-yl)-butyramide
Inchi KeyHHXVOPHNZVITID-UHFFFAOYSA-N
Inchi IDInChI=1S/C29H29F2N3O3S/c1-38(36,37)34-15-13-23(14-16-34)26(10-12-29(35)33-25-9-11-27(30)28(31)18-25)22-7-5-21(6-8-22)24-4-2-3-20(17-24)19-32/h2-9,11,17-18,23,26H,10,12-16H2,1H3,(H,33,35)
PubChem CID44412837
ChEMBLCHEMBL208081
IUPHARN/A
BindingDB50186781
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki<3000.0 nMPMID16690312BindingDB,ChEMBL

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