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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	GNF-Pf-3343
Molecular formula	C21H27ClN4OS
IUPAC name	3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methylthieno[2,3-c]pyrazole-5-carboxamide
Molecular weight	418.984
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.3
Synonyms	MolPort-007-635-639 ZINC5025926 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-thieno[2,3-c]pyrazole-5-carboxamide BDBM51913 MCULE-8675634474 CHEMBL599943 NCGC00108997-01 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-1H-thieno[2,3-c]pyrazole-5-carboxamide HMS1826E01 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methylthieno[2,3-c]pyrazole-5-carboxamide C509-0116 MLS001199353 cid_16007420 SMR000560359 3-(4-chlorophenyl)-N-[2-(dipropylamino)ethyl]-1-methyl-5-thieno[2,3-c]pyrazolecarboxamide HMS2875J05 AKOS001819039 [ Show all ]
Inchi Key	HGWOFUAZIPRWPO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H27ClN4OS/c1-4-11-26(12-5-2)13-10-23-20(27)18-14-17-19(24-25(3)21(17)28-18)15-6-8-16(22)9-7-15/h6-9,14H,4-5,10-13H2,1-3H3,(H,23,27)
PubChem CID	16007420
ChEMBL	CHEMBL599943
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6575.0 nM	PubChem BioAssay data set	ChEMBL

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