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Name | Neuropeptide Y receptor type 1 |
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Species | Homo sapiens (Human) |
Gene | NPY1R |
Synonym | neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor [ Show all ] |
Disease | Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder [ Show all ] |
Length | 384 |
Amino acid sequence | MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI |
UniProt | P25929 |
Protein Data Bank | 5zbh |
GPCR-HGmod model | P25929 |
3D structure model | This structure is from PDB ID 5zbh. |
BioLiP | BL0411971 |
Therapeutic Target Database | T89213 |
ChEMBL | CHEMBL4777 |
IUPHAR | 305 |
DrugBank | N/A |
Name | CHEMBL42747 |
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Molecular formula | C30H35N5O3 |
IUPAC name | N-[5-(diaminomethylideneamino)-1-(7-hydroxy-1,3,4,5-tetrahydro-2-benzazepin-2-yl)-1-oxopentan-2-yl]-2,2-diphenylacetamide |
Molecular weight | 513.642 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 4 |
XlogP | 3.1 |
Synonyms | BDBM50090277 N-[4-Guanidino-1-(7-hydroxy-1,3,4,5-tetrahydro-benzo[c]azepine-2-carbonyl)-butyl]-2,2-diphenyl-acetamide |
Inchi Key | APXQNCYYJXLPGT-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C30H35N5O3/c31-30(32)33-17-7-14-26(29(38)35-18-8-13-23-19-25(36)16-15-24(23)20-35)34-28(37)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-6,9-12,15-16,19,26-27,36H,7-8,13-14,17-18,20H2,(H,34,37)(H4,31,32,33) |
PubChem CID | 44288067 |
ChEMBL | CHEMBL42747 |
IUPHAR | N/A |
BindingDB | 50090277 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 280.0 nM | PMID10915060 | BindingDB,ChEMBL |
IC50 | 670.0 nM | PMID10915060 | BindingDB,ChEMBL |
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