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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 1
Species	Homo sapiens (Human)
Gene	NPY1R
Synonym	neuropeptide Y receptor type 1 NPY-Y1 receptor NPY1-R FC5 Y1 receptor Y1-R [ Show all ]
Disease	Hypertension; Obesity; Heart disease Obesity Eating disorders reduction in food intake obesity anxiety Eating disorders reduction in food intake Eating disorder Cardiovascular disorder Hypertension [ Show all ]
Length	384
Amino acid sequence	MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
UniProt	P25929
Protein Data Bank	5zbh
GPCR-HGmod model	P25929
3D structure model	This structure is from PDB ID 5zbh.
BioLiP	BL0411971
Therapeutic Target Database	T89213
ChEMBL	CHEMBL4777
IUPHAR	305
DrugBank	N/A

Ligand

Name	MLS000705653
Molecular formula	C17H26N2O4S
IUPAC name	N-[4-(hexylsulfamoyl)phenyl]oxolane-2-carboxamide
Molecular weight	354.465
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	2.8
Synonyms	AC1NO5O7 HMS2549D08 N-{4-[(hexylamino)sulfonyl]phenyl}tetrahydro-2-furancarboxamide AKOS021621182 MolPort-001-581-383 ST50624692 CHEMBL1353075 N-[4-(hexylsulfamoyl)phenyl]tetrahydrofuran-2-carboxamide AJ-292/42218533 MCULE-4247629691 REGID_for_CID_5132730 BDBM42572 N-[4-(hexylsulfamoyl)phenyl]-2-oxolanecarboxamide STK138788 cid_5132730 N-{4-[(hexylamino)sulfonyl]phenyl}oxolan-2-ylcarboxamide AKOS003326107 SMR000231050 N-[4-(hexylsulfamoyl)phenyl]oxolane-2-carboxamide [ Show all ]
Inchi Key	APXMICVTOJLGHL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H26N2O4S/c1-2-3-4-5-12-18-24(21,22)15-10-8-14(9-11-15)19-17(20)16-7-6-13-23-16/h8-11,16,18H,2-7,12-13H2,1H3,(H,19,20)
PubChem CID	5132730
ChEMBL	CHEMBL1353075
IUPHAR	N/A
BindingDB	42572
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	13680.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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