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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Neuropeptide Y receptor type 5
Species	Homo sapiens (Human)
Gene	NPY5R
Synonym	NPYY5-R NPY5-R NPY-Y5 receptor neuropeptide Y receptor type 5 food intake receptor Y5 receptor [ Show all ]
Disease	Eating disorder; Obesity Eating disorder; Obesity; Diabetes Major depressive disorder Obesity
Length	445
Amino acid sequence	MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
UniProt	Q15761
Protein Data Bank	N/A
GPCR-HGmod model	Q15761
3D structure model	This predicted structure model is from GPCR-EXP Q15761.
BioLiP	N/A
Therapeutic Target Database	T20331
ChEMBL	CHEMBL4561
IUPHAR	308
DrugBank	N/A

Ligand

Name	CHEMBL1912066
Molecular formula	C19H24N4O4S3
IUPAC name	N-[5-[[4-[1-(benzenesulfonyl)pyrrol-3-yl]-1,3-thiazol-2-yl]amino]pentyl]methanesulfonamide
Molecular weight	468.605
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	3.1
Synonyms	BDBM50355829
Inchi Key	APWIBTPOEWJHGI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H24N4O4S3/c1-29(24,25)21-12-7-3-6-11-20-19-22-18(15-28-19)16-10-13-23(14-16)30(26,27)17-8-4-2-5-9-17/h2,4-5,8-10,13-15,21H,3,6-7,11-12H2,1H3,(H,20,22)
PubChem CID	57396287
ChEMBL	CHEMBL1912066
IUPHAR	N/A
BindingDB	50355829
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	740.0 nM	PMID21924902	BindingDB,ChEMBL

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