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GLASS

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GPCR

Name	Relaxin receptor 2
Species	Homo sapiens (Human)
Gene	RXFP2
Synonym	RXFPR2 RXFP2 relaxin/insulin like family peptide receptor 2 relaxin receptor 2 Relaxin family peptide receptor 2 LGR8 Leucine-rich repeat-containing G-protein coupled receptor 8 leucine-rich repeat-containing G protein-coupled receptor 8 INSL3 receptor GPR106 G-protein coupled receptor affecting testicular descent G-protein coupled receptor 106 [ Show all ]
Disease	N/A
Length	754
Amino acid sequence	MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
UniProt	Q8WXD0
Protein Data Bank	2m96
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 2m96.
BioLiP	BL0278456
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628482
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	852168-54-8
Molecular formula	C15H17N7O3S2
IUPAC name	N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(1,3,7-trimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetamide
Molecular weight	407.467
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	1.2
Synonyms	HMS2981H18 AC1MOSU4 MolPort-003-040-938 CHEMBL1469832 SMR000806012 MCULE-7861555949 AKOS024592631 N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-((2,6,8-trimethyl-5,7-dioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl)thio)acetamide F0654-0082 ZINC11758060 AB00684824-01 MLS001167257 N-(5-ethyl-1,3,4-thiadiazol-2-yl)-2-(1,3,7-trimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetamide [ Show all ]
Inchi Key	APVYMSKIUYPWIY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H17N7O3S2/c1-5-9-19-20-14(27-9)18-8(23)6-26-12-10-11(16-7(2)17-12)21(3)15(25)22(4)13(10)24/h5-6H2,1-4H3,(H,18,20,23)
PubChem CID	3348974
ChEMBL	CHEMBL1469832
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	10931.0 nM	PubChem BioAssay data set	ChEMBL

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