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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	SMR000060790
Molecular formula	C23H30ClN3O5S
IUPAC name	1-[4-(2-chlorophenyl)piperazin-1-yl]-3-(4-morpholin-4-ylsulfonylphenoxy)propan-2-ol
Molecular weight	496.019
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	2.3
Synonyms	HMS2476P05 MLS000879925 716375-58-5 1-[4-(2-chlorophenyl)piperazin-1-yl]-3-(4-morpholin-4-ylsulfonylphenoxy)propan-2-ol MCULE-1013665136 MolPort-004-247-293 AC1MHA8E Z56798473 CHEMBL1365201 MLS000054452 1-[4-(2-chlorophenyl)piperazin-1-yl]-3-[4-(morpholine-4-sulfonyl)phenoxy]propan-2-ol REGID_for_CID_2998739 AKOS034456025 [ Show all ]
Inchi Key	HFTBUYNKBZOJMS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H30ClN3O5S/c24-22-3-1-2-4-23(22)26-11-9-25(10-12-26)17-19(28)18-32-20-5-7-21(8-6-20)33(29,30)27-13-15-31-16-14-27/h1-8,19,28H,9-18H2
PubChem CID	2998739
ChEMBL	CHEMBL1365201
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92480.0 nM	PubChem BioAssay data set	ChEMBL

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