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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Probable C-C chemokine receptor type 3
Species	Mus musculus (Mouse)
Gene	Ccr3
Synonym	CC-CKR-3 MIP-1alphaRL-2 (mouse) MIP-1 alpha RL2 Macrophage inflammatory protein 1-alpha receptor-like 2 CKR3 chemokine (C-C motif) receptor 3 CC CKR3 CD193 CCR3 CCR-3 C-C CKR-3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNTDEIKTVVESFETTPYEYEWAPPCEKVRIKELGSWLLPPLYSLVFIIGLLGNMMVVLILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNEWGFGHYMCKMLSGFYYLALYSEIFFIILLTIDRYLAIVHAVFALRARTVTFATITSIITWGLAGLAALPEFIFHESQDSFGEFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIRLIFVVMIVFFIFWTPYNLVLLFSAFHSTFLETSCQQSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPFLPGEKMERTSSVSPSTGEQEISVVF
UniProt	P51678
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3406
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL363840
Molecular formula	C28H36FN7O
IUPAC name	1-[(1R,2S)-2-[[(3S)-3-[(4-fluorophenyl)methyl]piperidin-1-yl]methyl]cyclohexyl]-3-[3-(1-methyltetrazol-5-yl)phenyl]urea
Molecular weight	505.642
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	4.8
Synonyms	1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(3-(1-methyl-1H-tetrazol-5-yl)phenyl)urea BDBM50163634 SCHEMBL18840850 1-{(1R,2S)-2-[(S)-3-(4-Fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-3-[3-(1-methyl-1H-tetrazol-5-yl)-phenyl]-urea
Inchi Key	HEXTXRMVMKIBQR-RZPFDVGOSA-N
Inchi ID	InChI=1S/C28H36FN7O/c1-35-27(32-33-34-35)22-8-4-9-25(17-22)30-28(37)31-26-10-3-2-7-23(26)19-36-15-5-6-21(18-36)16-20-11-13-24(29)14-12-20/h4,8-9,11-14,17,21,23,26H,2-3,5-7,10,15-16,18-19H2,1H3,(H2,30,31,37)/t21-,23-,26+/m0/s1
PubChem CID	11272103
ChEMBL	CHEMBL363840
IUPHAR	N/A
BindingDB	50163634
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	20.0 nM	PMID15771462	BindingDB,ChEMBL

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