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GPCR

NameFree fatty acid receptor 2
SpeciesHomo sapiens (Human)
GeneFFAR2
SynonymFFA2R
G protein-coupled receptor 43
G-protein coupled receptor 43
GPCR3
GPR43
[ Show all ]
DiseaseAbortion
Diabetes
Length330
Amino acid sequenceMLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProtO15552
Protein Data BankN/A
GPCR-HGmod modelO15552
3D structure modelThis predicted structure model is from GPCR-EXP O15552.
BioLiPN/A
Therapeutic Target DatabaseT28213
ChEMBLCHEMBL5493
IUPHAR226
DrugBankN/A

Ligand

NameCHEMBL594838
Molecular formulaC15H17ClN2OS
IUPAC namemethyl (1Z,2S)-2-(4-chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanimidate
Molecular weight308.824
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.9
SynonymsBDBM50305937
(S)-methyl 2-(4-chlorophenyl)-3-methyl-N-(thiazol-2-yl)butanimidate
Inchi KeyHDRMLSKXRFARLT-SSICXYGWSA-N
Inchi IDInChI=1S/C15H17ClN2OS/c1-10(2)13(11-4-6-12(16)7-5-11)14(19-3)18-15-17-8-9-20-15/h4-10,13H,1-3H3/b18-14-/t13-/m0/s1
PubChem CID46226436
ChEMBLCHEMBL594838
IUPHARN/A
BindingDB50305937
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy>30.0 %PMID20005104ChEMBL
IC50<100000.0 nMPMID20005104BindingDB,ChEMBL

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