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GPCR

NamePlatelet-activating factor receptor
SpeciesMus musculus (Mouse)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEHNGSFRVDSEFRYTLFPIVYSVIFILGVVANGYVLWVFANLYPSKKLNEIKIFMVNLTMADLLFLITLPLWIVYYYNEGDWILPNFLCNVAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGISLSLIIWVSIVATASYFLATDSTNLVPNKDGSGNITRCFEHYEPYSVPILVVHVFIAFCFFLVFFLIFYCNLVIIHTLLTQPMRQQRKAGVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVIVPANQTPIVSLKN
UniProtQ62035
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3993
IUPHAR334
DrugBankN/A

Ligand

NameCHEMBL349582
Molecular formulaC31H47IN2O4
IUPAC nameN-acetyl-4-methoxy-N-[(1-methylpyridin-1-ium-2-yl)methyl]-3-tetradecoxybenzamide;iodide
Molecular weight638.631
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogPNone
SynonymsSCHEMBL9306917
SCHEMBL9592700
2-[[Acetyl[4-methoxy-3-(tetradecyloxy)benzoyl]-amino]methyl]-1-methylpyridinium iodide
HDOMXXAPBXQNHG-UHFFFAOYSA-M
Inchi KeyHDOMXXAPBXQNHG-UHFFFAOYSA-M
Inchi IDInChI=1S/C31H47N2O4.HI/c1-5-6-7-8-9-10-11-12-13-14-15-18-23-37-30-24-27(20-21-29(30)36-4)31(35)33(26(2)34)25-28-19-16-17-22-32(28)3;/h16-17,19-22,24H,5-15,18,23,25H2,1-4H3;1H/q+1;/p-1
PubChem CID9986578
ChEMBLCHEMBL349582
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Survival21.0 %PMID8496938ChEMBL

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