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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Prostaglandin D2 receptor
Species	Homo sapiens (Human)
Gene	PTGDR
Synonym	PGD2 receptor DP1 DP1 receptor PTGDR1 prostanoid DP receptor-like Prostanoid DP receptor prostaglandin D2 receptor (DP) PGD receptor [ Show all ]
Disease	Pain Dyslipidaemias Rhinitis Thromboembolism Thrombosis Atopic dermatitis Asthma Allergy Allergic rhinitis [ Show all ]
Length	359
Amino acid sequence	MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
UniProt	Q13258
Protein Data Bank	N/A
GPCR-HGmod model	Q13258
3D structure model	This predicted structure model is from GPCR-EXP Q13258.
BioLiP	N/A
Therapeutic Target Database	T68782
ChEMBL	CHEMBL4427
IUPHAR	338
DrugBank	BE0000296

Ligand

Name	CHEMBL1081534
Molecular formula	C26H23F3N2O3
IUPAC name	N-[(2S,4R)-2-methyl-1-[3-(trifluoromethoxy)benzoyl]-3,4-dihydro-2H-quinolin-4-yl]-N-phenylacetamide
Molecular weight	468.476
Hydrogen bond acceptor	6
Hydrogen bond donor	0
XlogP	5.6
Synonyms	BDBM50312285 N-((2S,4R)-2-methyl-1-(3-(trifluoromethoxy)benzoyl)-1,2,3,4-tetrahydroquinolin-4-yl)-N-phenylacetamide
Inchi Key	APNWRWKPGBJTMO-BXKMTCNYSA-N
Inchi ID	InChI=1S/C26H23F3N2O3/c1-17-15-24(31(18(2)32)20-10-4-3-5-11-20)22-13-6-7-14-23(22)30(17)25(33)19-9-8-12-21(16-19)34-26(27,28)29/h3-14,16-17,24H,15H2,1-2H3/t17-,24+/m0/s1
PubChem CID	46879377
ChEMBL	CHEMBL1081534
IUPHAR	N/A
BindingDB	50312285
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<10000.0 nM	PMID19896843	BindingDB,ChEMBL

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