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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Platelet-activating factor receptor
Species	Rattus norvegicus (Rat)
Gene	Ptafr
Synonym	AGEPC receptor PAF receptor PAF-R PAFr
Disease	N/A for non-human GPCRs
Length	341
Amino acid sequence	MEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProt	P46002
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4127
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL100547
Molecular formula	C27H29N5O
IUPAC name	2-[4-(3-anilino-3-phenylpropanoyl)piperazin-1-yl]-2-(2-methylpyridin-3-yl)acetonitrile
Molecular weight	439.563
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	4.0
Synonyms	BDBM50045961 SCHEMBL9575234 (2-Methyl-pyridin-3-yl)-[4-(3-phenyl-3-phenylamino-propionyl)-piperazin-1-yl]-acetonitrile [4-[3-Phenyl-1-oxo-3-(phenylamino)propyl]piperazin-1-yl](2-methyl-3-pyridyl)acetonitrile
Inchi Key	HBGPXVSHANSTKF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H29N5O/c1-21-24(13-8-14-29-21)26(20-28)31-15-17-32(18-16-31)27(33)19-25(22-9-4-2-5-10-22)30-23-11-6-3-7-12-23/h2-14,25-26,30H,15-19H2,1H3
PubChem CID	10048850
ChEMBL	CHEMBL100547
IUPHAR	N/A
BindingDB	50045961
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
ID50	0.042 mg.kg-1	PMID8411016	ChEMBL

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