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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL336816
Molecular formulaC27H29N5O
IUPAC nameN-[2-[4-[cyano(pyridin-3-yl)methyl]piperazin-1-yl]ethyl]-2,2-diphenylacetamide
Molecular weight439.563
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP3.1
SynonymsSCHEMBL9853092
BDBM50003484
N-{2-[4-(Cyano-pyridin-3-yl-methyl)-piperazin-1-yl]-ethyl}-2,2-diphenyl-acetamide; hydrate
Inchi KeyHBGGHIHCBLBGLS-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H29N5O/c28-20-25(24-12-7-13-29-21-24)32-18-16-31(17-19-32)15-14-30-27(33)26(22-8-3-1-4-9-22)23-10-5-2-6-11-23/h1-13,21,25-26H,14-19H2,(H,30,33)
PubChem CID10433324
ChEMBLCHEMBL336816
IUPHARN/A
BindingDB50003484
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5036.0 nMPMID1433215BindingDB,ChEMBL

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