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GLASS

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GPCR

Name	Metabotropic glutamate receptor 1
Species	Rattus norvegicus (Rat)
Gene	Grm1
Synonym	mGluR1 SCAR13 mGlu1 receptor metabotropic glutamate receptor 1 wobl GPRC1A glutamate receptor, metabotropic 1 glutamate receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	1199
Amino acid sequence	MVRLLLIFFPMIFLEMSILPRMPDRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQTLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGWWPNAELTGCEPIPVRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKPGAGNANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDASTKTLYNVEEEDNTPSAHFSPPSSPSMVVHRRGPPVATTPPLPPHLTAEETPLFLADSVIPKGLPPPLPQQQPQQPPPQQPPQQPKSLMDQLQGVVTNFGSGIPDFHAVLAGPGTPGNSLRSLYPPPPPPQHLQMLPLHLSTFQEESISPPGEDIDDDSERFKLLQEFVYEREGNTEEDELEEEEDLPTASKLTPEDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVTYASVILRDYKQSSSTL
UniProt	P23385
Protein Data Bank	1iss, 1isr, 1ewk
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 1iss.
BioLiP	BL0023849, BL0023850,BL0023851, BL0011887,BL0011889, BL0011888,BL0011890
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4477
IUPHAR	289
DrugBank	N/A

Ligand

Name	2485-33-8
Molecular formula	C5H9NO5
IUPAC name	(2S,4R)-2-amino-4-hydroxypentanedioic acid
Molecular weight	163.129
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	-4.1
Synonyms	(2S,4R)-gamma-Hydroxyglutamic acid AKOS006271402 erythro-4-hydroxy-L-glutamic acid L-erythro-4-hydroxyglutamic acid (2S,4R)-2-amino-4-hydroxypentanedioic acid (4S)-4-hydroxy-L-glutamic acid H-(2S,4R)-Gamma-Hydroxy-Glu-OH ZINC895967 (2S,4R)-g-4-Hydroxy-L-glutamic Acid 7033AH DTXSID90331532 J-015700 (4R)-4-Hydroxy-L-glutamic acid C05947 FT-0669646 L-Glutamic acid,4-hydroxy-,(4R)- (2S,4R)-4-Hydroxy-L-glutamic Acid CHEMBL371946 H-(2S,4R)-Glu(g-OH)-OH (2S,4R)-gamma-Hydroxy-glutamic acid AC1L9A2D erythro-(4R)-4-Hydroxy-L-glutamic acid L-erythro-4-Hydroxyglutamate (4R)-4-Hydroxy-L-glutamic acid, >=98.0% (TLC) CHEBI:21285 H-(2S,4R)--Hydroxy-Glu-OH SCHEMBL5819946 (2S,4R)-4-Hydroxyglutamic Acid CTK8F1736 H-(2S,4R)-\|A-Hydroxy-Glu-OH [ Show all ]
Inchi Key	HBDWQSHEVMSFGY-STHAYSLISA-N
Inchi ID	InChI=1S/C5H9NO5/c6-2(4(8)9)1-3(7)5(10)11/h2-3,7H,1,6H2,(H,8,9)(H,10,11)/t2-,3+/m0/s1
PubChem CID	440854
ChEMBL	CHEMBL371946
IUPHAR	N/A
BindingDB	50100941
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	373000.0 nM	PMID11412983	BindingDB,ChEMBL
Rmax	70.0 mM	PMID11412983	ChEMBL

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