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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Prostaglandin E2 receptor EP1 subtype
Species	Rattus norvegicus (Rat)
Gene	Ptger1
Synonym	EP1 prostanoid receptor EP1 receptor PGE receptor EP1 subtype PGE2 receptor EP1 subtype prostaglandin E receptor 1 (subtype EP1), 42kDa prostanoid EP1 receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	405
Amino acid sequence	MSPYGLNLSLVDEATTCVTPRVPNTSVVLPTGGNGTSPALPIFSMTLGAVSNVLALALLAQVAGRLRRRRSTATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALALLAAMALAVALLPLVHVGHYELQYPGTWCFISLGPPGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRENAGPDDRRRWGSRGLRLASASSASSITSTTAALRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELSLTKSAWEASSLRSSRHSGFSHL
UniProt	P70597
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5068
IUPHAR	340
DrugBank	N/A

Ligand

Name	SCHEMBL6117972
Molecular formula	C23H20N2O3
IUPAC name	6-[(5-methoxy-6-methyl-2-phenylindol-1-yl)methyl]pyridine-2-carboxylic acid
Molecular weight	372.424
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.4
Synonyms	BDBM119466 US8680120, 25-16 CHEMBL3665560
Inchi Key	HAFKGXRVBBECLT-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H20N2O3/c1-15-11-20-17(13-22(15)28-2)12-21(16-7-4-3-5-8-16)25(20)14-18-9-6-10-19(24-18)23(26)27/h3-13H,14H2,1-2H3,(H,26,27)
PubChem CID	69670955
ChEMBL	CHEMBL3665560
IUPHAR	N/A
BindingDB	119466
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	39.0 nM	, None	BindingDB,ChEMBL

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