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GPCR

Name	Metabotropic glutamate receptor 4
Species	Rattus norvegicus (Rat)
Gene	Grm4
Synonym	glutamate receptor GPRC1D mGlu4 receptor mGluR4
Disease	N/A for non-human GPCRs
Length	912
Amino acid sequence	MSGKGGWAWWWARLPLCLLLSLYAPWVPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDGTEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGESGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARGIIIFANEDDIRRVLEAARRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFHCKLSRHALKKGSHIKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGRVGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNGSAEYKVIGSWTDHLHLRIERMQWPGSGQQLPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIVKLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFILISLQLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQNVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLETPALATKQTYVTYTNHAI
UniProt	P31423
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2787
IUPHAR	292
DrugBank	N/A

Ligand

Name	(2S,1'S,2'S)-2-(carboxycyclopropyl)glycine
Molecular formula	C6H9NO4
IUPAC name	(1S,2S)-2-[(S)-amino(carboxy)methyl]cyclopropane-1-carboxylic acid
Molecular weight	159.141
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	-3.4
Synonyms	L-2-(Carboxypropyl)glycine NCGC00024541-02 Tox21_500374 B6264 D0Z7CZ L-CCG-l NCGC00024541-05 (1S,2S)-2-[(1S)-1-amino-2-hydroxy-2-oxoethyl]cyclopropane-1-carboxylic acid 2S,1'S,2'S)-2-(Carboxycyclopropyl)Glycine CCG-204469 HMS3261K09 LP00374 SR-01000075799 (2S,3S,4S)-CCG AC1NSJQB CHEMBL280563 L-CCG-1 NCGC00024541-03 ZINC2568218 (1S,2S)-2-((S)-Amino(carboxy)methyl)cyclopropanecarboxylic acid 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid BDBM50034504 EU-0100374 L-CCGI NCGC00261059-01 (2S,1 inverted exclamation markaS,2 inverted exclamation markaS)-2-(Carboxycyclopropyl)glycine 3,4-Cyclopropylglutamate CCPG J-003677 MolPort-003-940-678 SR-01000075799-1 117857-93-9 AKOS006275493 Cyclopropaneacetic acid, alpha-amino-2-carboxy-, (alphaS,1S,2S)- L-Ccg-I NCGC00024541-04 (1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanecarboxylic acid 2-(Amino-carboxy-methyl)-cyclopropanecarboxylic acid(2S,3S,4S-CCG) C-237 GTPL1368 Lopac0_000374 SCHEMBL664330 [ Show all ]
Inchi Key	GZOVEPYOCJWRFC-HZLVTQRSSA-N
Inchi ID	InChI=1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3-,4-/m0/s1
PubChem CID	5310956
ChEMBL	CHEMBL280563
IUPHAR	1368
BindingDB	50034504
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	4000.0 nM	PMID14711315	BindingDB,ChEMBL
IC50	10000.0 - 50118.7 nM	PMID1330184	IUPHAR
Ki	8900.0 nM	PMID8863838	BindingDB

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