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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL1079186
Molecular formula	C25H32N4O2S
IUPAC name	4-butyl-N-[3-[(5-methyl-1H-imidazol-4-yl)methyl]-1,2,4,5-tetrahydro-3-benzazepin-7-yl]benzenesulfonamide
Molecular weight	452.617
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	4.7
Synonyms	BDBM50415674
Inchi Key	APDFBNVDTYKUDI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H32N4O2S/c1-3-4-5-20-6-10-24(11-7-20)32(30,31)28-23-9-8-21-12-14-29(15-13-22(21)16-23)17-25-19(2)26-18-27-25/h6-11,16,18,28H,3-5,12-15,17H2,1-2H3,(H,26,27)
PubChem CID	46882395
ChEMBL	CHEMBL1079186
IUPHAR	N/A
BindingDB	50415674
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	3.98 nM	PMID19804969	BindingDB
EC50	3.981 nM	PMID19804969	ChEMBL
Intrinsic activity	0.6 -	PMID19804969	ChEMBL

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