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GPCR

NamePlatelet-activating factor receptor
SpeciesRattus norvegicus (Rat)
GenePtafr
SynonymAGEPC receptor
PAF receptor
PAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length341
Amino acid sequenceMEQNGSFRVDSEFRYTLFPIVYSVIFVLGVVANGYVLWVFATLYPSKKLNEIKIFMVNLTVADLLFLMTLPLWIVYYSNEGDWIVHKFLCNLAGCLFFINTYCSVAFLGVITYNRYQAVAYPIKTAQATTRKRGITLSLVIWISIAATASYFLATDSTNVVPKKDGSGNITRCFEHYEPYSVPILVVHIFITSCFFLVFFLIFYCNMVIIHTLLTRPVRQQRKPEVKRRALWMVCTVLAVFVICFVPHHVVQLPWTLAELGYQTNFHQAINDAHQITLCLLSTNCVLDPVIYCFLTKKFRKHLSEKFYSMRSSRKCSRATSDTCTEVMMPANQTPVLPLKN
UniProtP46002
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4127
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL173104
Molecular formulaC26H22FN5O2
IUPAC name6-(4-fluorophenyl)-N,N-dimethyl-3-[2-(2-methylimidazo[4,5-c]pyridin-1-yl)acetyl]indole-1-carboxamide
Molecular weight455.493
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.0
Synonyms6-(4-Fluoro-phenyl)-3-[2-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-acetyl]-indole-1-carboxylic acid dimethylamide
BDBM50062080
SCHEMBL7492384
Inchi KeyGYPDWEMMDNUGPB-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H22FN5O2/c1-16-29-22-13-28-11-10-23(22)31(16)15-25(33)21-14-32(26(34)30(2)3)24-12-18(6-9-20(21)24)17-4-7-19(27)8-5-17/h4-14H,15H2,1-3H3
PubChem CID10551722
ChEMBLCHEMBL173104
IUPHARN/A
BindingDB50062080
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
ED50<1.0 mg.kg-1PMID9438024ChEMBL

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