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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL171294
Molecular formulaC27H30N6O4
IUPAC namemethyl 1-(dimethylcarbamoyl)-3-[2-[4-(2-methylimidazo[4,5-c]pyridin-1-yl)piperidin-1-yl]acetyl]indole-4-carboxylate
Molecular weight502.575
Hydrogen bond acceptor7
Hydrogen bond donor0
XlogP2.5
SynonymsBDBM50062094
1-Dimethylcarbamoyl-3-{2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-piperidin-1-yl]-acetyl}-1H-indole-4-carboxylic acid methyl ester
Inchi KeyGYOXBIRWEXESML-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H30N6O4/c1-17-29-21-14-28-11-8-22(21)33(17)18-9-12-31(13-10-18)16-24(34)20-15-32(27(36)30(2)3)23-7-5-6-19(25(20)23)26(35)37-4/h5-8,11,14-15,18H,9-10,12-13,16H2,1-4H3
PubChem CID10767781
ChEMBLCHEMBL171294
IUPHARN/A
BindingDB50062094
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki19.0 nMPMID9438024BindingDB,ChEMBL

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