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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	MLS000759653
Molecular formula	C21H26N4O8S
IUPAC name	N-(2-methyl-5-morpholin-4-ylsulfonylphenyl)-2-(pyridin-3-ylmethylamino)acetamide;oxalic acid
Molecular weight	494.519
Hydrogen bond acceptor	11
Hydrogen bond donor	4
XlogP	None
Synonyms	HMS2764E13 MolPort-004-250-922 Z56833075 MCULE-6157494846 N-[2-methyl-5-(morpholine-4-sulfonyl)phenyl]-2-{[(pyridin-3-yl)methyl]amino}acetamide; oxalic acid CHEMBL1457587 SMR000369450 AKOS034459140 [ Show all ]
Inchi Key	GYOIRLYWPIRHDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H24N4O4S.C2H2O4/c1-15-4-5-17(28(25,26)23-7-9-27-10-8-23)11-18(15)22-19(24)14-21-13-16-3-2-6-20-12-16;3-1(4)2(5)6/h2-6,11-12,21H,7-10,13-14H2,1H3,(H,22,24);(H,3,4)(H,5,6)
PubChem CID	16239891
ChEMBL	CHEMBL1457587
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 10 hydrogen bond acceptor. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92470.0 nM	PubChem BioAssay data set	ChEMBL

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