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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Prostaglandin D2 receptor
Species	Homo sapiens (Human)
Gene	PTGDR
Synonym	PGD2 receptor DP1 DP1 receptor PTGDR1 prostanoid DP receptor-like Prostanoid DP receptor prostaglandin D2 receptor (DP) PGD receptor [ Show all ]
Disease	Pain Dyslipidaemias Rhinitis Thromboembolism Thrombosis Atopic dermatitis Asthma Allergy Allergic rhinitis [ Show all ]
Length	359
Amino acid sequence	MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
UniProt	Q13258
Protein Data Bank	N/A
GPCR-HGmod model	Q13258
3D structure model	This predicted structure model is from GPCR-EXP Q13258.
BioLiP	N/A
Therapeutic Target Database	T68782
ChEMBL	CHEMBL4427
IUPHAR	338
DrugBank	BE0000296

Ligand

Name	CHEMBL365829
Molecular formula	C28H25NO5
IUPAC name	2-[1-[4-(3,4-dihydro-2H-chromen-2-ylmethoxy)benzoyl]-2-methylindol-4-yl]acetic acid
Molecular weight	455.51
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	5.5
Synonyms	{1-[4-(Chroman-2-ylmethoxy)-benzoyl]-2-methyl-1H-indol-4-yl}-acetic acid BDBM50152514 SCHEMBL5853087
Inchi Key	GWYIZWZVKYKMGF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H25NO5/c1-18-15-24-21(16-27(30)31)6-4-7-25(24)29(18)28(32)20-10-12-22(13-11-20)33-17-23-14-9-19-5-2-3-8-26(19)34-23/h2-8,10-13,15,23H,9,14,16-17H2,1H3,(H,30,31)
PubChem CID	21974374
ChEMBL	CHEMBL365829
IUPHAR	N/A
BindingDB	50152514
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	30.0 nM	PMID15341946	BindingDB,ChEMBL
Ki	50.0 nM	PMID15341946	BindingDB,ChEMBL

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