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GPCR

NamePlatelet-activating factor receptor
SpeciesCavia porcellus (Guinea pig)
GenePTAFR
SynonymPAF-R
PAFr
DiseaseN/A for non-human GPCRs
Length342
Amino acid sequenceMELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
UniProtP21556
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5136
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL367425
Molecular formulaC27H31N5O4
IUPAC namemethyl 1-(dimethylcarbamoyl)-3-[7-(2-methylimidazo[4,5-c]pyridin-1-yl)heptanoyl]indole-4-carboxylate
Molecular weight489.576
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP3.5
SynonymsBDBM50062115
SCHEMBL7493124
1-Dimethylcarbamoyl-3-[7-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-heptanoyl]-1H-indole-4-carboxylic acid methyl ester
Inchi KeyGWSHLSXPHSDTOP-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H31N5O4/c1-18-29-21-16-28-14-13-22(21)31(18)15-8-6-5-7-12-24(33)20-17-32(27(35)30(2)3)23-11-9-10-19(25(20)23)26(34)36-4/h9-11,13-14,16-17H,5-8,12,15H2,1-4H3
PubChem CID10505183
ChEMBLCHEMBL367425
IUPHARN/A
BindingDB50062115
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki9.4 nMPMID9438024BindingDB,ChEMBL

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