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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Free fatty acid receptor 2
Species	Homo sapiens (Human)
Gene	FFAR2
Synonym	FFA2R G protein-coupled receptor 43 G-protein coupled receptor 43 GPCR3 GPR43 FFA2 receptor [ Show all ]
Disease	Abortion Diabetes
Length	330
Amino acid sequence	MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
UniProt	O15552
Protein Data Bank	N/A
GPCR-HGmod model	O15552
3D structure model	This predicted structure model is from GPCR-EXP O15552.
BioLiP	N/A
Therapeutic Target Database	T28213
ChEMBL	CHEMBL5493
IUPHAR	226
DrugBank	N/A

Ligand

Name	CHEMBL606629
Molecular formula	C18H17ClF6N2O2S
IUPAC name	(2S)-2-(4-chlorophenyl)-N-[5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-1,3-thiazol-2-yl]-3,3-dimethylbutanamide
Molecular weight	474.846
Hydrogen bond acceptor	10
Hydrogen bond donor	2
XlogP	5.7
Synonyms	BDBM50305917 (S)-2-(4-chlorophenyl)-N-(5-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)thiazol-2-yl)-3,3-dimethylbutanamide
Inchi Key	GVUGZEAXWZZCPP-LBPRGKRZSA-N
Inchi ID	InChI=1S/C18H17ClF6N2O2S/c1-15(2,3)12(9-4-6-10(19)7-5-9)13(28)27-14-26-8-11(30-14)16(29,17(20,21)22)18(23,24)25/h4-8,12,29H,1-3H3,(H,26,27,28)/t12-/m0/s1
PubChem CID	46226312
ChEMBL	CHEMBL606629
IUPHAR	N/A
BindingDB	50305917
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Efficacy	113.0 %	PMID20005104	ChEMBL
IC50	1200.0 nM	PMID20005104	BindingDB,ChEMBL

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